Phenotypes of juvenile idiopathic arthritis

Phenotypes of juvenile idiopathic arthritis

Introduction The term “phenotype” comes from the Greek word “phaino” are is the mix of characteristics and properties of the body, formed in the process of individual development. In medicine phenotype has traditionally been viewed as the result of the interaction of the genotype (genetic characteristics of the organism to the conditions of external environment. Different authors in the allocat...

TH17-phenotypes of juvenile idiopathic arthritis

Introduction Juvenile idiopathic arthritis (JIA) is a chronic disorder with unknown etiology and characterized by autoimmunity, infiltration of synovium by activated proinflammatory cells, synovial hyperplasia and progressive destruction of cartilage and bone. IL-17A is a proinflammatory cytokine that is expressed in the inflamed synovium. Th17 cells have been identified as main producers of th...

Multicentric Carpotarsal Osteolysis Mimicking Juvenile Idiopathic Arthritis

Background Multicentric carpotarsal osteolysis (MCTO), a skeletal dysplasia presents in early childhood mimicking juvenile idiopathic arthritis (JIA). Recognition of this syndrome is essential to avoid unnecessary treatment with immunosuppressive agents because of different course and treatment. Case Report A 3-year-old boy presented with swelling and restriction of right wrist joint and left ...

Juvenile idiopathic arthritis.

Juvenile idiopathic arthritis (JIA), a term referring to a group of disorders characterized by chronic arthritis, is the most common chronic rheumatic illness in children and is a significant cause of short- and long-term disability. This article discusses the classification, differential diagnosis, and treatment of JIA.

Juvenile Idiopathic Arthritis